However, the mechanism of TDP-43 pathology in neurodegeneration resulting from repeated head trauma is unknown. We previously demonstrated that 

The TDP-43 pathology in Perry syndrome defies subclassification due to absence of lesions in the cortex and hippocampus and the consistent involvement of the SN and globus pallidus, which are brain regions not even considered in FTLD-U subclassification schemes.

06/09/  · Objective: Although a systematic spread of pathologic TDP-43 expression throughout the CNS in amyotrophic lateral sclerosis (ALS) has been proposed, the relationship between cognition and the extent and neuroanatomic distribution of TDP-43 pathology has not received considerable attention.

A prominent pathological feature of all TDP-43 proteinopathies is nuclear depletion of the TDP-43 protein, which is mostly seen in the end stages of the disease 

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01/04/2022 · Distinct pathological TDP-43 species contribute differentially to cellular dysfunction and toxicity. Neuronal proteostasis failure facilitates TDP-43 aggregation in ALS, FTD, and other neurodegenerative diseases. TDP-43 aggregation impairs protein degradation systems to potentiate disease.

05/05/  · TDP-43 inclusions are characterized by a large spectrum of neurodegenerative diseases such as ALS and Alzheimer's. Functionally, TDP-43 is engaged in forming dynamic

No significant patterns of inward surface deformity were associated with amyloid-beta or transactive response DNA-binding protein of 43 kDA after including covariates. Our findings indicate that hippocampal shape deformity measures in surface zones approximating CA1 may represent a biomarker for postmortem AD pathology.

We found that, among the 110 ALS cases, minor (C)-allele homozygotes at the TMEM106B locus sentinel SNP rs1990622 had more TDP-43 pathology 

TDP-43 strains have also been isolated from FTLD-TDP brain tissues, which induces the formation of morphologically distinct aggregates in cells, and induces distinct morphological and subcellular distribution of TDP-43 pathology in transgenic mice . Although these studies showed TDP-43 polymorphs both in vitro and in vivo, TDP-43 strains in co

14/02/  · Thus, unraveling the molecular mechanisms of the TDP-43 pathology seems central to the ALS therapeutics, hence, we comprehensively review the current understanding of the